Synaptic organization of visual space in primary visual cortex. Orientation selectivity and the functional clustering of synaptic inputs in primary visual cortex. Activity-dependent clustering of functional synaptic inputs on developing hippocampal dendrites. Kleindienst, T., Winnubst, J., Roth-Alpermann, C., Bonhoeffer, T. A clustered plasticity model of long-term memory engrams. Branch-specific plasticity enables self-organization of nonlinear computation in single neurons. Submillisecond precision of the input-output transformation function mediated by fast sodium dendritic spikes in basal dendrites of CA1 pyramidal neurons. State-dependent dendritic computation in hippocampal CA1 pyramidal neurons. Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons. Dendritic integration: 60 years of progress. Pathway interactions and synaptic plasticity in the dendritic tuft regions of CA1 pyramidal neurons. Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons. Distance-dependent differences in synapse number and AMPA receptor expression in hippocampal CA1 pyramidal neurons. Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites. Impaired spatial representation in CA1 after lesion of direct input from entorhinal cortex. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning. Nucleus reuniens of the thalamus contains head direction cells. Major dissociation between medial and lateral entorhinal input to dorsal hippocampus. A prefrontal-thalamo-hippocampal circuit for goal-directed spatial navigation. Place cells and place recognition maintained by direct entorhinal-hippocampal circuitry. On the integration of space, time, and memory. A cortical-hippocampal system for declarative memory. Our results suggest that distinct afferent projections use different connectivity motifs that differentially contribute to dendritic integration.Įichenbaum, H. Computational simulations revealed that compound connections depolarize dendrites in a biophysically efficient manner, owing to their inherent spatiotemporal clustering. These compound connections exhibit ultrastructural features indicative of strong synapses and occur much more commonly in entorhinal than in thalamic afferents. Here we show that single presynaptic axons form multiple, spatially clustered inputs onto the distal, but not proximal, dendrites of CA1 pyramidal neurons. While it is known that synchronous activation of spatially clustered inputs can contribute to firing through the generation of dendritic spikes, there is no established mechanism for spatiotemporal synaptic clustering. Feature-selective firing of these neurons results from the dendritic integration of inputs from multiple brain regions. CA1 pyramidal neurons are a major output of the hippocampus and encode features of experience that constitute episodic memories.
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